Proteostasis
Proteostasis Science
     

 

 

Selected Publications

Reviews

Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging.
Morimoto RI.
Genes Dev. 2008 Jun 1;22(11):1427-38. Review.

Adapting proteostasis for disease intervention.
Balch WE, Morimoto RI, Dillin A, Kelly JW.
Science. 2008 Feb 15;319(5865):916-9. Review.
[ Free article at journal site ]

Heat shock response modulators as therapeutic tools for diseases of protein conformation.
Westerheide SD, Morimoto RI.
J Biol Chem. 2005 Sep 30;280(39):33097-100. Epub 2005 Aug 1. Review.
[ Free article at journal site ]

Publications

Discovery and characterization of a mammalian amyloid disaggregation activity.
Murray AN, Solomon JP, Wang YJ, Balch WE, Kelly JW.
Protein Sci. 2010 Feb 16;19(4):836-846.

[Epub ahead of print]

Reduced IGF-1 Signaling Delays Age-Associated Proteotoxicity in Mice.
Cohen E, Paulsson JF, Blinder P, Burstyn-Cohen T, Du D, Estepa G, Adame A, Pham HM, Holzenberger M, Kelly JW, Masliah E, Dillin A.
Cell. Volume 139, Issue 6, 1157-1169, 11 December 2009.
[ Free article at journal site ]

Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis.
Hutt DM, Herman D, Rodrigues AP, Noel S, Pilewski JM, Matteson J, Hoch B, Kellner W, Kelly JW, Schmidt A, Thomas PJ, Matsumura Y, Skach WR, Gentzsch M, Riordan JR, Sorscher EJ, Okiyoneda T, Yates JR 3rd, Lukacs GL, Frizzell RA, Manning G, Gottesfeld JM, Balch WE.
Nat Chem Biol. 2009 Dec 6. [ Epub ahead of print ]

Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1.
Westerheide SD, Anckar J, Stevens SM Jr, Sistonen L, Morimoto RI.
Science. 2009 Feb 20;323(5917):1063-6.

Regulation of the cellular heat shock response in Caenorhabditis elegans by thermosensory neurons.
Prahlad V, Cornelius T, Morimoto RI.
Science. 2008 May 9;320(5877):811-4.

Chemical and biological approaches synergize to ameliorate protein-folding diseases.
Mu TW, Ong DS, Wang YJ, Balch WE, Yates JR 3rd, Segatori L, Kelly JW.
Cell. 2008 Sep 5;134(5):769-81.

Partial restoration of mutant enzyme homeostasis in three distinct lysosomal storage disease cell lines by altering calcium homeostasis.
Mu TW, Fowler DM, Kelly JW.
PLoS Biol. 2008 Feb;6(2):e26.
[ Free article in PMC | at journal site ]

Opposing activities protect against age-onset proteotoxicity.
Cohen E, Bieschke J, Perciavalle RM, Kelly JW, Dillin A.
Science. 2006 Sep 15;313(5793):1604-10. Epub 2006 Aug 10.

Progressive disruption of cellular protein folding in models of polyglutamine diseases.
Gidalevitz T, Ben-Zvi A, Ho KH, Brignull HR, Morimoto RI.
Science. 2006 Mar 10;311(5766):1471-4. Epub 2006 Feb 9.
[ Free article at journal site ]