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The Proteostasis NetworkEvery cell and tissue in the body needs to maintain protein homeostasis, or proteostasis, to ensure health. The Proteostasis Network in a cell regulates a complex network of interacting biological processes to maintain proteostasis. When working properly, the Proteostasis Network ensures that every protein will reach its final destination in the cell fully functional or be eliminated to prevent damage. Functions of the Proteostasis Network include folding required for protein function, degradation of misfolded or misassembled proteins, and the transport of proteins to appropriate locations in the cell.
If the Proteostasis Network is compromised, every cell type in the body can potentially be affected resulting in a progressive decline of organ function. The inability of the cell to maintain the proper balance of the Proteostasis Network can be due, broadly speaking, to either intrinsic genetic defects or to the cumulative effects of environmental and cellular stresses. Proteostasis Regulators are designed to rebalance the Proteostasis Network, either by restoring it to its "normal" state or augmenting the capacity of the compromised Proteostasis Network to a "therapeutic" state that is sufficient to control or delay progression of disease.
Proteostasis Therapeutics, Inc. is developing a broad platform of integrated capabilities in order to convert the emerging knowledge of the Proteostasis Network and its function to discover new therapeutics for previously intractable diseases. This network analysis effort is initially directed to mapping out the Proteostasis Network in normal and diseased states, so that the resulting understanding of its organization can be used to enable the discovery and development of a new class of drugs and to characterize their mechanisms of action. The platform will also have utility for optimizing dosing regimens and patient stratification purposes, as well as non-therapeutic applications such as biomarker discovery.
Map of Protein Interaction Networks Involved in Proteostasis
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